"Accommodating Covariates in ROC Analysis" by Holly Janes

# Accommodating covariates in roc analysis online. Econpapers: accommodating covariates in receiver operating characteristic analysis

The point of covariate adjustment is to consider different groups homogeneous due to lower prevalence and interaction in the risk model between distinct strata. Therefore, regression models are introduced into the ROC analysis.

Just as the Cox model allows for stratification of the survival curve, they propose giving stratified reliability measures. Simulation studies show that the grouped variable selection is superior to separate model selections.

## Computational and Mathematical Methods in Medicine

This is because [just roll with this], even if a rich person showed manic and depressive symptoms, they'll probably never try meth.

The reason this matters to us might be justified in the context of a binary mixed effects model: The difference will result in difficulties in interpretation, because it is natural to expect that the same set of variables contributes to discriminating diseased and nondiseased subjects.

However, a poor person would show a much larger increased risk having such psychological symptoms and higher risk score. In Section 2we rewrite the ROC regression into a grouped variable selection form so that current criteria accommodating covariates in roc analysis online be applied.

We describe three ways of using covariate information.

## Accommodating Covariates in ROC Analysis.

If many covariates are available, the variable selection issue arises. Wang and Fang [ 16 ] successfully applied the FIC to variable selection in linear models and demonstrated that the FIC exactly improved the estimation performance of singled-out parameters.

Pepe [ 3 ] and Zhou et al.

This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. By following notations of the local model, which generalizes the commonly used sparsity assumption, homoscedastic regression models for diseased and nondiseased subjects are assumed as follows: The area under the ROC curve AUC is an important one-number summary index of the overall discriminative accuracy of a ROC curve, by taking the influence of all cutoff values into account.

In studies of classification accuracy, there are often covariates that should be incorporated into the ROC analysis.

Let be the response of a diseased subject, and let be the response of a nondiseased subject; then, the AUC can be expressed as [ 2 ].

I should have anticipated your response, given your reply here or another response of yours on the medstats mailing-list. If there are many covariates, the variable selection issue arises in terms of the consideration of model interpretation and estimability.

Pepe Stata Journal, vol. This is a method of stratifying ROC curves among specific groups in the population of interest.

Introduction In modern medical diagnosis or genetic studies, the receiver operating characteristic ROC curve is a popular tool to evaluate the discrimination performance of a certain biomarker on a disease status or a phenotype.

Abstract Regression models are introduced into the receiver operating characteristic ROC analysis to accommodate effects of covariates, such as genes.

Additionally, although the number of genes is large, there may be only a small number of them associated with the disease risk or phenotype. Initially, we require that all covariates be centered at 0 for the consideration of comparability.

The estimated true positive fraction TPF; eq.

## Epidemiology - Adjusting for covariates in ROC curve analysis - Cross Validated

For example, in a continuous-scale test, the diagnosis of a disease is dependent upon whether a test result is above or below a specified cutoff value. Alternatively, they developed the focused information criterion FICwhich focuses on a parameter singled out for interests. By varying cutoff values throughout the entire real line, the resulting plot of sensitivity against 1-specificity is a ROC curve.

A brief discussion is provided in Section 6. Firstly, if we model outcomes of diseased and nondiseased subjects separately, selected submodels may be different. In this paper, we obtain one single objective function with the group SCAD to select grouped variables, which adapts to popular criteria of model selection, and propose a two-stage framework to apply the focused information criterion FIC.

The remaining parts of this paper are organized as follows. For a given cutoff value of a biomarker or a combination of biomarkers, the sensitivity and the specificity are employed to quantitatively evaluate the discriminative performance.

## Accommodating Covariates in ROC Analysis. - PubMed - NCBI

Some asymptotic properties of the proposed methods are derived. Accommodating covariates in receiver operating characteristic analysis Holly Janes, Gary M. Volume 09, issue Number 1, 23 Abstract: For factors that affect marker observations among controls, we present a method for covariate adjustment.

Secondly, most current criteria for variable selection procedures focus on the prediction performance or variable selection consistency. Simulation studies and a real data analysis are given in Sections 4 and 5.

Two possible reasons may account for this situation. SES has such an obvious dominating effect on this that it seems foolish to evaluate a diagnostic test, which might be based on personal behaviors, without somehow stratifying.

### Supplemental Content

There are two main groups of variable selection procedures. If not, we can center responses to finish the model selection and then add centers back to evaluate the AUC. All proofs are presented in the Supplement; see Supplementary Materials available online at http: The crude analysis of risk would show very poor performance of your predictive model because the same differences in two groups were not reliable.

Longton and Margaret S.

## Result Filters

The insight behind this criterion is that a model that gives good precision for one estimand may be worse when used in inference for another estimand. Furthermore, in the ROC regression, the accuracy of area under the curve AUC should be the focus instead of aiming at the consistency of model selection or the good prediction performance.

Also, genome-wide association studies in human populations aim at creating genomic profiles which combine the effects of many associated genetic variants to predict the disease risk of a new subject with high discriminative accuracy [ 1 ].

The traditional induced methodology separately models outcomes of diseased and nondiseased groups; thus, separate application of variable selections to two models will bring barriers in interpretation, due to differences in selected models. In this paper, we focus on the induced methodology, to which current model selection techniques may be extended.

At a glance, it sounds like what you're trying to do is improve your diagnostic test by incorporating more markers into your panel.