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ELABELA has also been found to be expressed in human embryonic stem cells, indicating that it might have other functions beyond its role in cardiovascular development.

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Hormones are known to control functions flirtonomics as sleep, appetite and fertility. However, this is the first time that scientists have revealed the existence of flirtonomics conserved[1] hormone playing such an early role during embryogenesis, effectively orchestrating the development of an entire organ.

It is an excellent example of how basic research can lead to surprising and unexpected findings that may change and refine medical practice.

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Loss of Ela causes embryos to develop with a rudimentary heart flirtonomics no heart at all, surprisingly phenocopying the loss of the apelin receptor aplnrwhich we show serves as Ela's cognate G protein-coupled receptor.

As some people might have a harmful copy of the ELABELA gene in their genetic make-up, sequencing and screening for this particular gene in the general population might also help to detect predisposition to heart anomalies before the disease progresses.

That we can still find anonymous hormones charms me. Deficiencies in hormones are the cause of many diseases, such as the loss of insulin or insulin resistance, that results in diabetes, and irregularities in appetite and satiety hormones that can cause obesity. Present in human embryonic stem cells, ELA is expressed at the onset of zebrafish zygotic transcription and is ubiquitous in the naive ectodermal cells of the embryo.

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Dr Bruno Reversade said, "The human genome has been sequenced over a decade ago. Ela null embryos have impaired endoderm differentiation potential marked by reduced gata5 and sox17expression. Mutations in the Apelin Receptor also prevent the heart from forming.

There are a still a few more to discover…but not for long.

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Using zinc-finger-nuclease-mediated gene inactivation in zebrafish, we created an allelic series of ela mutants. The team's findings hold great promise for the potential use of ELABELA as a therapeutic molecule for cardiovascular disease to be used in cardiac repair and control of hypertension.

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Zebrafish bereft of the Apelin Receptor are referred to as the Grinch, in reference to the cold and heartless cartoon character created by Dr.