Peptidylglycine alpha-amidating monooxygenase mwe, result filters
The multifunctional peptidylglycine alpha-amidating monooxygenase gene: A comparison of PAM activity and DDC levels in 30 lung cancer cell lines indicated that peptide amidating activity may be an indicator of NE status .
Although some of the truncated PAM protein was also processed and stored in AtT cells, much of the expressed protein was redistributed to the plasma membrane .
The high expression of peptidylglycine alpha-amidating monooxygenase mRNA in glioblastoma and glioma cell lines points to the involvement of alpha-amidated peptides in tumorigenic growth processes in the brain .
Disease relevance of PAM Long-term follow-up of these patients for new second primary lung cancers may help to determine the potential predictive value of PAM detected in the BAL fluid . Blood acid-base status, serum electrolytes, and urine pH were examined in 64 infants and children with phenylketonuria PKU treated with three different low phenylalanine protein hydrolyzates Aponti, Cymogran, AlbumaidXP and two synthetic amino acid mixtures Aminogran, PAM .
Chemical compound and disease context of PAM 4-Phenylbutenoic acid PBA is an irreversible turnover-dependent peptidylglycine alpha-amidating monooxygenase mwe of PAM in vitro and has been shown to decrease lung cancer cell proliferation by inhibiting the synthesis of amidated growth factors .
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PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila. WikiGenes is a non-profit and open access community project - Read more.
Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text. Peptidylglycine alpha-amidating monooxygenase is the enzyme producing alpha-amidated bioactive peptides from their inactive glycine -extended precursors .
Psychiatry related information on PAM Of the cerebral cortical regions examined, only the temporal pole showed reduced PAM activity in patients with Alzheimer's disease AD compared with controls . The plasminogen binding domain of PAM is highly variable, and this variation has been linked to host selective immune pressure .
The optimal pH for amidating activity was 5.
Peptidylglycine alpha-amidating monooxygenase - Wikiwand
PHM share protein sequence similarity with dopamine-beta-monooxygenases DBHa class of ascorbate-dependent enzymes that requires copper as a cofactor and uses ascorbate as an electron donor.
Characterization of novel mRNAs encoding enzymes involved in peptide alpha-amidation.
To characterize the trafficking of integral membrane PAM proteins in neuroendocrine cells, we have generated stable AtT cell lines expressing full length and COOH-terminally truncated integral membrane PAM proteins .
Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase .
Peptidylglycine alpha-amidating monooxygenase
Between and28 patients with locally advanced cervical adenocarcinoma bulky IB-IIIB were recruited for a pilot study aimed at evaluation of the effectiveness of neoadjuvant chemotherapy with cisplatinaclacinomycin-Aand mitomycin-C PAMfollowed by radical surgery . If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.
In a randomized Phase II study, the authors evaluated the activity and toxicity of the new cisplatindoxorubicinand mitomycin C PAM combination, that includes cisplatin P instead of 5-fluorouracil as in the 5-fluorouracildoxorubicinand mitomycin C FAM combination, in patients with advanced gastric carcinoma .
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However in contradistinction to patients with medullary thyroid carcinoma, PAM activity does not appear to be a useful tumour marker of gastrinoma . There have been significant advances in the understanding of the dioxygen -activation chemistry of mononuclear copper monooxygenases such as peptidylglycine alpha-amidating monooxygenase and dopamine beta-monooxygenase DbetaM .
The protein contains two enzymes, peptidylglycine alpha-hydroxylating monooxygenase PHM and peptidyl-alpha-hydroxyglycine alpha-amidating lyase PALthat act sequentially to catalyse the alpha-amidation of neuroendocrine peptides [ PMID: New insights into copper monooxygenases and peptide amidation: PAM mRNA levels were found to be 3-fold higher in prostate adenocarcinomas compared with that of human benign prostate hyperplasia BPH as demonstrated by real-time quantitative reverse transcription-PCR .
Levels of alpha-amidating activity, peptidyl-glycine alpha-amidating monooxygenase PAMwere reduced in the CSF of patients with dementia of the Alzheimer type DAT compared with healthy, age-matched controls .
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Much of the current information on this page has been automatically compiled from Pubmed. The first step of the reaction is catalysed by peptidylglycine alpha-hydroxylating monooxygenase PHMand is dependent on copper, ascorbate and molecular oxygen; peptidyl-alpha-hydroxyglycine alpha-amidating lyase PAL catalyses the second step of the reaction [ PMID: Description In vertebrates, peptidylglycine alpha-amidating monooxygenase PAM is a multifunctional protein found in secretory granules.
The copper-enzyme family of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase: